Journal: Neuroimage

Article Title: Organization of the macaque monkey inferior parietal lobule based on multimodal receptor architectonics

doi: 10.1016/j.neuroimage.2021.117843

Figure Lengend Snippet: Location and extent of IPL areas in the macaque monkey brain. A : 3D reconstruction of the left hemisphere (in lateral view) of Macaca mulatta (DP1) brain obtained using Connectome Workbench software ( https://www.humanconnectome.org/software/connectome-workbench ) showing the location and extent of the areas that compose the IPL (map made publicly available at https://balsa.wustl.edu/study/7qgpZ). The enlarged reconstruction scheme indicates the approximate positions of cut plane (a-i) for a series of exemplary coronal sections, which were processed for the visualization of topography of IPL areas. B - E : Low magnification views of representative fields of IPL areas taken from the four exemplary coronal sections. For each section, the dashed boxes indicate the location of the photomicrographs; arrows indicate the borders between cytoarchitectonic areas. The cytoarchitectonic subdivisions of the IPL convexity, areas Opt, PG, PFG and PF, are shown in B, C, D and E , respectively. The opercular area PGop is shown in C , PFop are shown in D and E . Dorsal is up and lateral on the right. Scale bar, 500 μm.

Article Snippet: Upon publication, the ensuing 3D map of the macaque IPL, and the receptor fingerprints will be made publicly available to the neuroscientific community via the Human Brain Project and BALSA repositories.

Techniques: Software

Journal: Neuroimage

Article Title: Organization of the macaque monkey inferior parietal lobule based on multimodal receptor architectonics

doi: 10.1016/j.neuroimage.2021.117843

Figure Lengend Snippet: Comparison of laminar receptor densities of kainate receptor in IPL areas. A : Coronal sections through four caudo-rostral levels of a macaque hemisphere showing kainate receptor distribution patterns in the IPL. The borders between the IPL areas (red lines) are charted on the pseudocolor-coded autoradiographs. The color bar beneath each autoradiograph indicates receptor concentrations by the different colors, from dark blue for low to red for high concentrations (fmol/mg protein). B : Laminar distribution pattern of representative fields of IPL areas. Roman numerals indicate cytoarchitectonic layers. C : Bar plot shows receptor densities in each layer for the IPL areas, separately. Receptor densities (y axis) are given in fmol/mg protein. Brackets across bars denote the areas which have significant inter-area differences in laminar densities (* p < 0.05, ** p < 0.01).

Article Snippet: Upon publication, the ensuing 3D map of the macaque IPL, and the receptor fingerprints will be made publicly available to the neuroscientific community via the Human Brain Project and BALSA repositories.

Techniques: Comparison, Autoradiography

Journal: Neuroimage

Article Title: Organization of the macaque monkey inferior parietal lobule based on multimodal receptor architectonics

doi: 10.1016/j.neuroimage.2021.117843

Figure Lengend Snippet: The absolute mean areal densities and laminar densities of seven exemplary receptor types (i.e. GABA B , GABA A /BZ, M 2 , α 1 , 5-HT 1A , 5-HT 2 and D 1 ) have been projected onto the corresponding IPL areas. Color bars code for receptor densities in fmol/mg protein. The projections of other receptor types onto the Yerkes 19 surface are shown in S12 Figure. The file coding for the densities of all 15 receptors in each area is provided as Supplementary data 1, and is made available to the neuroscientific community via the Human Brain Project (https://kg.ebrains.eu/search/instances/Project/e39a0407-a98a-480e-9c63-4a2225ddfbe4) and BALSA (https://balsa.wustl.edu/study/7qgpZ) repositories.

Article Snippet: Upon publication, the ensuing 3D map of the macaque IPL, and the receptor fingerprints will be made publicly available to the neuroscientific community via the Human Brain Project and BALSA repositories.

Techniques:

Journal: Neuroimage

Article Title: Organization of the macaque monkey inferior parietal lobule based on multimodal receptor architectonics

doi: 10.1016/j.neuroimage.2021.117843

Figure Lengend Snippet: A : Receptor fingerprints of the examined IPL areas. Absolute densities (fmol/mg protein) of 15 receptors are displayed in polar coordinate plots (scaling 0-2500 fmol/mg protein) of 6 brain areas. The corresponding transparent surface indicates the standard deviation. The positions of the different receptor types and the axis scaling are identical in all polar plots, and specified in the polar plot at the bottom right corner of the figure. B : Receptor-driven clustering of the monkey IPL areas. Hierarchical cluster analysis reveals 2 receptor-architectonically distinct clusters: a caudal cluster (red) consisting of areas Opt, PG and PGop; and a rostral cluster (blue) consisting of areas PFG, PF and PFop. C : Multi-Dimensional Scaling (MDS) analysis of the monkey IPL areas. The distances between areas represent the Eigenvalues of the first and second dimensions, two clusters are segregated by the first dimension, same color coding as in A .

Article Snippet: Upon publication, the ensuing 3D map of the macaque IPL, and the receptor fingerprints will be made publicly available to the neuroscientific community via the Human Brain Project and BALSA repositories.

Techniques: Standard Deviation

Journal: Neuroimage

Article Title: Organization of the macaque monkey inferior parietal lobule based on multimodal receptor architectonics

doi: 10.1016/j.neuroimage.2021.117843

Figure Lengend Snippet: Comparative analysis of human and macaque IPL areas. A : Multidimensional scaling analysis reveals the segregation of human and macaque areas by the first dimension, whereas the second dimension reflects changes in receptor fingerprints along the rostro-caudal axis of each species. Note, that to facilitate interpretation of the results, the MDS plot has been rotated counter-clockwise by 90° and flipped horizontally. Thus, human areas are found at the top of the plot and macaque areas at the bottom. Rostral areas are to the left, caudal ones to the right. Dashed lines with arrows connect homolog areas. B : Schematic representation of the topographic relationship between IPL areas in the human (top) and macaque (bottom) brains. Colour coding represents clusters as revealed by hierarchical cluster analyses, the detailed information of macaque clusters can be found in Figure 6 . Three receptor-architectonically distinct clusters in human were found by Caspers S et al. : a caudal cluster (red) consisting of areas PGp and PGa; an intermediate cluster (green) consisting of areas PFm and PF, and a rostral cluster (blue) consisting of areas PFt, PFcm and PFop. Abbreviations: ips intraparietal sulcus, lf lateral fissure.

Article Snippet: Upon publication, the ensuing 3D map of the macaque IPL, and the receptor fingerprints will be made publicly available to the neuroscientific community via the Human Brain Project and BALSA repositories.

Techniques:

Journal: Microorganisms

Article Title: Anti-Virulence Properties of Coridothymus capitatus Essential Oil against Pseudomonas aeruginosa Clinical Isolates from Cystic Fibrosis Patients

doi: 10.3390/microorganisms9112257

Figure Lengend Snippet: Three-dimensional reconstruction of C (untreated sample) and F (CCEO treated sample). ( A , B ) represent the 3D reconstruction of the untreated sample; ( C , D ) illustrate the 3D reconstruction of the treated sample. Lower areas are represented in dark blue; mild and high elevated areas correspond to ECM mesh frames, color varies from yellow and red (high elevated areas). The deep channels areas are represented in blue, and the trabecular system in turquoise-green (mildly elevated areas) and yellow-red (highest areas). ( A ) untreated sample; ( B ) treated sample.

Article Snippet: Three-dimensional reconstruction was undertaken by Hitachi Map 3D Software (v.8.2., Digital surf, Besançon, France) [ ].

Techniques:

Journal: Microorganisms

Article Title: Anti-Virulence Properties of Coridothymus capitatus Essential Oil against Pseudomonas aeruginosa Clinical Isolates from Cystic Fibrosis Patients

doi: 10.3390/microorganisms9112257

Figure Lengend Snippet: Three-dimensional reconstruction of C (untreated sample) and F (CCEO treated sample). Lower areas are represented in dark blue; mild-elevated areas are represented in turquoise-green; the color of high-elevated areas varies from yellow to red. ( A ) represents the 3D reconstruction of the untreated sample of C. ( B ) is the extracted circular area from ( A ) represented in false colors. ( C ) represents the 3D reconstruction of the treated sample of F; ( D ) illustrates the extracted circular area from ( C ).

Article Snippet: Three-dimensional reconstruction was undertaken by Hitachi Map 3D Software (v.8.2., Digital surf, Besançon, France) [ ].

Techniques: